Mode VC

Isaac Manke

Partner atAcorn BioventuresNew York
Acorn Bioventures websiteFirm profile

Isaac Manke is a life sciences venture capitalist. He currently serves as a General Partner at Acorn BioVentures.

What Isaac can write

Writes checks of$100K to $10M
Comes in atSeed, Series A, Series BCan lead the round
Best routeA warm introAsk a founder in their portfolio.

Acorn Bioventures writes $100K to $10M checks, larger than 5% of firms in the atlas.

Bars: how many firms report each check band. Highlighted: Acorn Bioventures.

Career

  1. Massachusetts Institute of Technology · research scientist
  2. Health Advances · Senior Analyst
  3. Deutsche Bank · Biotechnology Equity Research group
  4. Sanford C. Bernstein · Associate Equity Analyst
  5. New Leaf Venture Partners · General Partner
  6. Acorn BioVentures · General Partner
    Now

Investments named in public bios

ONK Therapeutics

Focus

life sciencesbiotechnologybiopharmaceuticalmedical device

Education

Minnesota State University (Moorhead), BA in Biology and a BA in ChemistryMIT, PhD in Biophysical Chemistry and Molecular Structure

Also at Acorn Bioventures

Anders HoveFounder & Partner
Gabriel SchneiderVice President
Max LewinVice President

Partners like Isaac

At firms with a similar stage, sector and check size.

Ann DeWitt
Ann DeWittGeneral Partner, The Engine
Peter LeeGeneral Partner, Embark Ventures
Aryeh GanzManaging Partner, Cornucopian Capital
Michael Liao
Michael LiaoManaging Director, Heuristic Capital
Shaun A. KirkpatrickPresident, Biotechnologies, Research Corporation Technologies
Jack W. Lasersohn
Jack W. LasersohnGeneral Partner, The Vertical Group

Alert me when Acorn Bioventures is active

One email when Isaac's firm raises a fund, adds a partner or shows new activity.

Founders and investors at a Mode VC gathering

Send Mode VC your deck

Raising a pre-seed or seed round? We write $1M to $5M first checks and help founders with distribution. A partner reads every deck.

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Questions

Who is Isaac Manke?

Isaac Manke is a life sciences venture capitalist. He currently serves as a General Partner at Acorn BioVentures.

How much does Isaac Manke invest?

Isaac Manke invests through Acorn Bioventures, which writes checks of $100K to $10M at seed, series a, series b.

How do I pitch Isaac Manke?

A warm intro from a founder Acorn Bioventures backed works best.

What did Isaac Manke do before Acorn Bioventures?

research scientist at Massachusetts Institute of Technology; Senior Analyst at Health Advances; Biotechnology Equity Research group at Deutsche Bank; Associate Equity Analyst at Sanford C. Bernstein; General Partner at New Leaf Venture Partners.

Last updated 2026-10-15. Is this you? Ask for a correction.