Mode VC
Jonathan Leff

Jonathan Leff

Executive Partner, Private Equity atSofinnova InvestmentsCalifornia
Full bioFirm profile

Jonathan Leff is an Executive Partner at Sofinnova Investments with over 25 years in biotech and pharma drug development. He focuses on strategic drug development and serves on boards of Axonis, Expedition, and NorthSea.

What Jonathan can write

Writes checks of$10M to $30M
Comes in atSeries A, Series BCan lead the round
Ownership target7-10%At first check
Email the firm[email protected]The firm's own inbox for founders.

Sofinnova Investments writes $10M to $30M checks, larger than 97% of firms in the atlas.

Bars: how many firms report each check band. Highlighted: Sofinnova Investments.

Career

  1. Halozyme Therapeutics · Vice President and Chief Medical Officer
  2. KaloBios Pharmaceuticals · Chief Medical Officer
  3. InterMune · Executive Vice President, Research and Development
  4. Ascendis Pharma · Senior Vice President and Chief Medical Officer
  5. Merck
  6. Amgen
  7. Roche
  8. Sofinnova · Executive Partner, Private Equity
    Now

Investments named in public bios

AxonisExpeditionNorthSea

Focus

drug developmentbiotechnologypharmaceuticalclinical developmentpulmonary

Education

University of Pennsylvania, B.A. in ChemistryUniversity of Pennsylvania School of Medicine, M.D.University of Colorado, Denver, medical training in Internal Medicine and Pulmonary and Critical Care Medicine

Also at Sofinnova Investments

Jim Healy
Jim HealyManaging Partner
Maha Katabi
Maha KatabiGeneral Partner
Chris Carpenter
Chris CarpenterExecutive Partner, Private Equity
Jakob Dupont
Jakob DupontExecutive Partner, Private Equity
Lars Ekman
Lars EkmanExecutive Partner, Private Equity
Maha Radhakrishnan
Maha RadhakrishnanExecutive Partner, Private Equity
Eric Hsu
Eric HsuAnalyst, Private Equity
Mike Van
Mike VanAssociate, Private Equity

Partners like Jonathan

At firms with a similar stage, sector and check size.

Ali Tamaseb
Ali TamasebGeneral Partner, DCVC
Srini Akkaraju
Srini AkkarajuFounder & Managing Partner, Samsara BioCapital
J. Matthew Mackowski
J. Matthew MackowskiChairman, Managing Director, Telegraph Hill Partners
David KabakoffFounding Senior Partner, HealthQuest Capital
Cariad Chester
Cariad ChesterManaging Partner, TCG Crossover
Pete Bastien
Pete BastienPresident & Partner, Hitachi Ventures

Alert me when Sofinnova Investments is active

One email when Jonathan's firm raises a fund, adds a partner or shows new activity.

Founders and investors at a Mode VC gathering

Send Mode VC your deck

Raising a pre-seed or seed round? We write $1M to $5M first checks and help founders with distribution. A partner reads every deck.

Send your deck

Questions

Who is Jonathan Leff?

Jonathan Leff is an Executive Partner at Sofinnova Investments with over 25 years in biotech and pharma drug development. He focuses on strategic drug development and serves on boards of Axonis, Expedition, and NorthSea.

How much does Jonathan Leff invest?

Jonathan Leff invests through Sofinnova Investments, which writes checks of $10M to $30M at series a, series b.

How do I pitch Jonathan Leff?

Email [email protected], the firm's inbox for founders, and name Jonathan in the subject. A warm intro from a founder Sofinnova Investments backed works better.

What did Jonathan Leff do before Sofinnova Investments?

Vice President and Chief Medical Officer at Halozyme Therapeutics; Chief Medical Officer at KaloBios Pharmaceuticals; Executive Vice President, Research and Development at InterMune; Senior Vice President and Chief Medical Officer at Ascendis Pharma; Merck; Amgen; Roche.

Last updated 2026-10-15. Is this you? Ask for a correction.