Missouri

RiverVest

RiverVest, based in Missouri, backs life sciences and healthtech startups from Pre-Seed to Series B, mostly leading rounds with checks from $3 million to $30 million.

Entry stagePre-seed, Seed, Series A, Series B
Check size$3M to $30M
Leads roundsYes
FocusLife sciences, Healthtech
Latest fund$275M Fund V (2021)
Investing team8 peopleNo activity since Sep

Who you would pitch at RiverVest

8 people on the investing team, 5 of them partners who can make the call. Partners are listed first.

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Writes $3M to $30M checks. Its smallest check is larger than 93% of firms in the atlas.

Bars: how many firms in the atlas report each band. Highlighted: this firm.

No recent activity since September 2026. Quiet does not mean closed.

Weekly count of activity updates. Activity is not a confirmed deal.

Before you pitch

Ownership target7-10%
How to reach them[email protected]

Notable investments

MacroGenicsMirum PharmaceuticalsXilio TherapeuticsSpruce Biosciences

In their words

RiverVest | Science. Strategy. Innovation.RiverVest is a leading venture capital firm building life science companies to address significant unmet medical needs.rivervest.com
Founders and investors at a Mode VC gathering

Send Mode VC your deck

Raising a pre-seed or seed round? We write $1M to $5M first checks and help founders with distribution. A partner reads every deck.

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Alert me when RiverVest is active

One email when this firm shows new activity. Nothing else.

Firms like RiverVest

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Questions

What stage does RiverVest invest in?

RiverVest reports entry at pre-seed, seed, series a, series b.

How much does RiverVest invest?

RiverVest reports checks of $3M to $30M.

Does RiverVest lead rounds?

Yes. RiverVest says it can lead.

Who are the partners at RiverVest?

Isaac Zike (Managing Director), Jay W. Schmelter (Co-Founder & Managing Director), Karen Spilizewski (Managing Director), Niall O'Donnell (Managing Director), Tom Melzer (Co-Founder & Managing Director).

Is RiverVest active right now?

No recent activity since September 2026.

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