Mode VC

Pre-seed deep tech investors

67 of 93 pre-seed deep tech firms that report a preference say they can lead. 7 active since September.

Can leadMostly followsNot reportedRecently active

Julian CapitalActive Oct 14

California

Julian Shapiro, Jacob Jackson+1 on the team

Pre-seedSeedLeadsDeep tech

$500K to $3MCan lead

The EngineActive Sep 22

Massachusetts · Fund $398M (Fund III) (2024)

Ann DeWitt, Israel Ruiz+9 on the team

Pre-seedSeedSeries ALeadsDeep tech +4

$250K to $10MCan lead

Arch Venture PartnersActive Sep 28

Illinois · Fund $3B+ Fund XIII (2024)

Paul Berns, Keith Crandell+12 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +1

$25K to $30M+Can lead

Two Small Fish VenturesActive Sep 23

Toronto · Fund $30M (Fund III)

Eva Lau, Albert Chen+2 on the team

Pre-seedSeedLeadsDeep tech

$1M to $3MCan lead

Valhalla VenturesActive Sep 30

Florida

Devan Malhotra, Rohan Pujara

Pre-seedSeedLeadsDeep tech +4

$500K to $10MCan lead

137 VenturesActive Sep 24

United States and Canada

Justin Fishner-Wolfson, Alex Jacobson+2 on the team

Pre-seedSeedSeries ASeries BFintech +3

$1M to $10MLead not reported

ConvergeActive Sep 27

Massachusetts

Anshu Agarwal, Maia Heymann+3 on the team

Pre-seedSeedSeries AEnterprise software +4

Check size not reportedLead not reported

California

Ben Patterson, Daniel Ramirez

Pre-seedLeadsDeep techConfirmed by the firm

$500K to $1MCan lead

California · Fund $240M (2022)

Hany Nada, Scott Stanford+3 on the team

Pre-seedSeedSeries ASeries BLeadsDeep tech +4

$1M to $30MCan lead

New York · Fund $50M (Fund II) (2026)

Mike Annunziata, Brandes Woodall

Pre-seedLeadsDeep techConfirmed by the firm

$100K to $500KCan lead

District of Columbia

David Michael, David Seldin+9 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +3

Check size not reportedCan lead

California

Don Sheu, Enrico Marini Fichera

Pre-seedSeedLeadsDev tools and infra +1

Check size not reportedCan lead

Azolla Ventures

Massachusetts · Fund $239M

Amy Duffuor, Johanna Wolfson+5 on the team

Pre-seedSeedLeadsClimate +2

Check size not reportedCan lead

Better Ventures

California · Fund $108M

Rick Moss, Wes Selke+1 on the team

Pre-seedSeedLeadsClimate +5

$500K to $1MCan lead

Florida · Fund $50M (2026)

Jamie Rutledge, Chris Cesareo+1 on the team

Pre-seedSeedSeries ALeadsDeep tech +6

$250K to $3MCan lead

Breakout Ventures

California · Fund $114M Fund III (2026)

Julia Moore, Lindy Fishburne+2 on the team

Pre-seedSeedSeries ALeadsLife sciences +2

$500K to $10MCan lead

Champion Hill Ventures

North Carolina

Josh Manchester, Robert Haddick

Pre-seedSeedLeadsDeep tech +1

$250K to $500KCan lead

Cortado Ventures

Oklahoma

Mike Moradi, Nathaniel Harding+2 on the team

Pre-seedSeedSeries ASeries BLeadsIndustrial +4Confirmed by the firm

$500K to $3MCan lead

Cottonwood Technology Fund

Colorado

Alain le Loux, Dave Blivin+5 on the team

Pre-seedSeedSeries ASeries BLeadsDeep tech +3

$1M to $30MCan lead

Massachusetts · Fund $350M

David Fallace, J.D. / M.B.A., Lou Tartaglia, Ph.D.+13 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +1

Check size not reportedCan lead

Elm Street Ventures

Connecticut

Chris McLeod, Rob Bettigole+1 on the team

Pre-seedSeedSeries ALeadsLife sciences +3

$500K to $1MCan lead

Embark Ventures

California

Peter Lee, Yipeng Zhao+1 on the team

Pre-seedSeedLeadsLife sciences +4

$100K to $3MCan lead

Fine Structure Venture

Massachusetts

Jennifer Uhrig, Shyam Kamadolli+4 on the team

Pre-seedSeedSeries ASeries BLeadsDeep tech

Check size not reportedCan lead

California

Ari Stiegler, Mike Loretz+2 on the team

Pre-seedSeedSeries ALeadsDeep tech +2

$250K to $10MCan lead

Foresite Capital

California · Fund $900M

Hyung Chun, MD, Shannon Bergstedt+11 on the team

Pre-seedSeedSeries ASeries BLeadsHealthtech +2

Check size not reportedCan lead

Freeflow Ventures

California · Fund $35M (2024)

David Fleck, Kevin Barrett

Pre-seedSeedSeries ALeadsDeep tech +3

Check size not reportedCan lead

California

Jay Eum, Jeff Herbst+1 on the team

Pre-seedSeedSeries ALeadsDeep tech +1

Check size not reportedCan lead

Glasswing Ventures

Massachusetts · Fund $200M+ Fund III (2025)

Kleida Martiro, Rick Grinnell+4 on the team

Pre-seedSeedLeadsDeep tech +2

Check size not reportedCan lead

Good Growth Capital

South Carolina

Amy Salzhauer, Carolyne LaSala+5 on the team

Pre-seedSeedSeries ALeadsLife sciences +1Confirmed by the firm

$250K to $3MCan lead

Hat-Trick Capital

California

Junguang (Peter) Pan, Gary Lin+1 on the team

Pre-seedSeedSeries ALeadsConsumer +3

$500K to $3MCan lead

Heuristic Capital

California

Michael Liao, Ren Du+1 on the team

Pre-seedSeedSeries ALeadsDeep tech +3

$100K to $1MCan lead

Indiana

Ginger Rothrock, Ph.D, John Glushik+4 on the team

Pre-seedSeedSeries ASeries BLeadsClimate +4

$1M to $10MCan lead

Massachusetts

John Murphy, Vivjan Myrto+2 on the team

Pre-seedSeedSeries ALeadsDeep tech +4

$250K to $3MCan lead

Infinite Capital

Florida

Nathan Doctor, Sean Doctor+2 on the team

Pre-seedSeedSeries ASeries BLeadsDefense and space +3

$3M to $30M+Can lead

Massachusetts · Fund $40 million

Alexander Lange, Jonatan Luther-Bergquist

Pre-seedSeedLeadsDefense and space +4

$500K to $1MCan lead

Massachusetts · Fund $250 million (2025)

Alexander Harstrick, Jonathan Bronson+3 on the team

Pre-seedSeedSeries ALeadsDeep tech +4

$1M to $10MCan lead

Texas · Fund Over (2024)

Cain McClary, Mack Healy+4 on the team

Pre-seedSeedSeries ALeadsLife sciences +1

$500K to $10MCan lead

Colorado

Jackson Vaughan, Jason Chapman+3 on the team

Pre-seedSeedSeries ALeadsDeep techConfirmed by the firm

$1M to $10MCan lead

New York · Fund $31M (Fund IV) (2024)

Evan Nisselson, Ash Cleary+1 on the team

Pre-seedSeedLeadsDeep techConfirmed by the firm

$500K to $3MCan lead

California

Karthee Madasamy, Ruchi Dana+2 on the team

Pre-seedSeedSeries ALeadsDeep tech

$1M to $10MCan lead

Founders and investors at a Mode VC gathering

Send Mode VC your deck

Raising a pre-seed or seed round? We write $1M to $5M first checks and help founders with distribution. A partner reads every deck.

Related lists

Pre-seed investors1696 Seed deep tech investors200 Pre-seed healthtech investors154 Series A deep tech investors146 Pre-seed fintech investors134 Pre-seed climate investors127 Pre-seed enterprise software investors125 Pre-seed dev tools and infra investors108 Pre-seed industrial investors107 Pre-seed life sciences investors95 Pre-seed crypto investors84 Pre-seed logistics and mobility investors69

Questions

How many pre-seed deep tech investors are there?

Mode VC tracks 120 firms on this list as of 2026-10-15. 7 have been active since September 2026.

What check size do pre-seed deep tech investors write?

The most reported band is $500K to $1M, reported by 39 firms on this list.

Which pre-seed deep tech investors lead rounds?

67 of 93 firms that report a preference say they can lead. Turn on "Leads rounds" to see only them.