Pre-seed life sciences investors

52 of 65 pre-seed life sciences firms that report a preference say they can lead. 3 active since September.

Can leadMostly followsNot reportedRecently active
The EngineActive Sep 22
Massachusetts · Fund $398M (Fund III) (2024)
Ann DeWitt, Israel Ruiz+9 on the team
Pre-seedSeedSeries ALeadsDeep tech +4
$250K to $10MCan lead
Illinois · Fund $3B+ Fund XIII (2024)
Paul Berns, Keith Crandell+12 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +1
$25K to $30M+Can lead
The Longevity FundActive Sep 24
California
Alex Colville, Satvik Dasariraju
Pre-seedSeedSeries ALeadsLife sciences
$500K to $10MCan lead
California · Fund $400M (2025)
Lenny Pruss, Mike Dauber+8 on the team
Pre-seedSeedSeries ALeadsDev tools and infra +2
$500K to $10MCan lead
Quebec · Fund C$263M Fund II (2024)
Dion Madsen, Jean-Francois Pariseau+7 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +1
Check size not reportedCan lead
California · Fund $200 million (2025)
Ken Horne, Ari Nowacek+9 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences
Check size not reportedCan lead
District of Columbia
David Michael, David Seldin+9 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +3
Check size not reportedCan lead
New York · Fund $2.9B committed capital
Seth L. Harrison, Anna Batarina+1 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences
$10M to $30M+Can lead
California · Fund $108M
Rick Moss, Wes Selke+1 on the team
Pre-seedSeedLeadsClimate +5
$500K to $1MCan lead
Michigan
Steve Haakenson, Shruti Bagla
Pre-seedSeedLeadsLife sciences
$100K to $250KCan lead
Florida · Fund $50M (2026)
Jamie Rutledge, Chris Cesareo+1 on the team
Pre-seedSeedSeries ALeadsDeep tech +6
$250K to $3MCan lead
California · Fund $114M Fund III (2026)
Julia Moore, Lindy Fishburne+2 on the team
Pre-seedSeedSeries ALeadsLife sciences +2
$500K to $10MCan lead
California
Karan Wadhera, Yoni Meyer+1 on the team
Pre-seedSeedSeries ASeries BLeadsConsumer +3
Check size not reportedCan lead
New York · Fund $2B AUM
George C. Petrocheilos, R. Jacob Vogelstein, Ph.D.+18 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +1
Check size not reportedCan lead
New Jersey
Aryeh Ganz, Jinny Choi+2 on the team
Pre-seedSeedSeries ASeries BLeadsHealthtech +3
$250K to $10MCan lead
Massachusetts · Fund $350M
David Fallace, J.D. / M.B.A., Lou Tartaglia, Ph.D.+13 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +1
Check size not reportedCan lead
New York
Nan Li, Zavain Dar+3 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciencesConfirmed by the firm
$3M to $30MCan lead
Massachusetts
Campbell Murray, Daniel Yadegar
Pre-seedSeedSeries ALeadsLife sciences +1
Check size not reportedCan lead
Connecticut
Chris McLeod, Rob Bettigole+1 on the team
Pre-seedSeedSeries ALeadsLife sciences +3
$500K to $1MCan lead
California
Peter Lee, Yipeng Zhao+1 on the team
Pre-seedSeedLeadsLife sciences +4
$100K to $3MCan lead
Massachusetts
Stephen Knight, Amber Cai+17 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +4
$1M to $30M+Can lead
California · Fund $900M (2025)
Aydin Senkut, James Detweiler+7 on the team
Pre-seedSeedSeries ALeadsCybersecurity +4
$1M to $30M+Can lead
Massachusetts · Fund $2.6B
Paul Biondi, Doug Cole, M.D.+1 on the team
Pre-seedSeedLeadsLife sciences +2
Check size not reportedCan lead
California · Fund $900M
Hyung Chun, MD, Shannon Bergstedt+11 on the team
Pre-seedSeedSeries ASeries BLeadsHealthtech +2
Check size not reportedCan lead
California · Fund $35M (2024)
David Fleck, Kevin Barrett
Pre-seedSeedSeries ALeadsDeep tech +3
Check size not reportedCan lead
California
Brian Frank, Jenn Burka
Pre-seedSeedLeadsLife sciencesConfirmed by the firm
$250K to $1MCan lead
South Carolina
Amy Salzhauer, Carolyne LaSala+5 on the team
Pre-seedSeedSeries ALeadsLife sciences +1Confirmed by the firm
$250K to $3MCan lead
Toronto
Pre-seedSeedLeadsHealthtech +1
Check size not reportedCan lead
California
Michael Liao, Ren Du+1 on the team
Pre-seedSeedSeries ALeadsDeep tech +3
$100K to $1MCan lead
Massachusetts · Fund $250 million (2025)
Alexander Harstrick, Jonathan Bronson+3 on the team
Pre-seedSeedSeries ALeadsDeep tech +4
$1M to $10MCan lead
Texas · Fund Over (2024)
Cain McClary, Mack Healy+4 on the team
Pre-seedSeedSeries ALeadsLife sciences +1
$500K to $10MCan lead
Massachusetts
Christoph Westphal, Rich Aldrich+4 on the team
Pre-seedSeedSeries ALeadsLife sciences
Check size not reportedCan lead
New York · Fund $145M Fund I (2022)
Brian Halak, Eric Heil+6 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences
$3M to $30MCan lead
Massachusetts · Fund $143.75M
Douglas Crawford, Johannes Fruehauf+10 on the team
Pre-seedSeedSeries ALeadsLife sciences
$25K to $10MCan lead
New York
Somu Subramaniam, Andrew Abrams+1 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +3
Check size not reportedCan lead
California · Fund $389 (2023)
Peter Bisgaard, Rob Hopfner+3 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences
$3M to $30MCan lead
Illinois · Fund $100 million AUM
John Flavin, Steven Lehmann
Pre-seedSeedLeadsLife sciences
$500K to $3MCan lead
Massachusetts · Fund $260 (2022)
Anna French, Mark McDade+4 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +1
$1M to $10MCan lead
California
Andrew Ogawa, Maarten 't Hooft+2 on the team
Pre-seedSeedLeadsDeep tech +3
$100K to $3MCan lead
Massachusetts · Fund $10B+ (2025)
Adam Kaye, Emily Minkow+35 on the team
Pre-seedSeedSeries ASeries BLeadsLife sciences +4
$3M to $30M+Can lead

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Questions

How many pre-seed life sciences investors are there?

Mode VC tracks 95 firms on this list as of 2026-10-15. 3 have been active since September 2026.

What check size do pre-seed life sciences investors write?

The most reported band is $500K to $1M, reported by 28 firms on this list.

Which pre-seed life sciences investors lead rounds?

52 of 65 firms that report a preference say they can lead. Turn on "Leads rounds" to see only them.