Massachusetts

F-Prime Capital

F-Prime Capital, based in Massachusetts, backs life sciences, healthtech, enterprise software, fintech, and crypto founders from Pre-Seed to Series B, mostly leading rounds with checks from $1 million to over $30 million.

Entry stagePre-seed, Seed, Series A, Series B
Check size$1M to $30M+
Leads roundsYes
FocusLife sciences, Healthtech, Enterprise software, Fintech, Crypto
Latest fundn/a
Investing team19 peopleNo activity since Sep

Who you would pitch at F-Prime Capital

19 people on the investing team, 15 of them partners who can make the call. Partners are listed first.

Stephen Knight
Stephen KnightSenior Managing PartnerHe invests broadly across healthcare and serves on multiple boards.
Amber Cai
Amber CaiPartnerShe founded Skyline Therapeutics and previously held leadership roles at Novartis in China and the US.
Carlos Bustamante
Carlos BustamantePartnerFocus: data science and genomics in medicine, agriculture, and biology.
Eric Blatte
Eric BlattePartnerHe has founded and led companies including RiskRecon, Trusteer, Imprivata, and Centra Software.
Hannah Arnold
Hannah ArnoldPartnerShe previously worked in tech investment, consulting, and international development.
Harlan Krumholz
Harlan KrumholzPartnerHe serves as the founding Director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation.
Jackson Wilkinson
Jackson WilkinsonPartnerHe previously held CTO and product leadership roles at several software firms.
Jay Farber
Jay FarberPartnerHe also serves as the General Manager of the technology business at Juniper Square.
John Vigeant
John VigeantPartnerHe previously led companies including Reddo Mobility and Tracelytics, and held business development roles at XenSource and Citrix.
Josh Feinblum
Josh FeinblumPartnerHe previously served as CSO at DigitalOcean and launched Rapid7's security organization, and advises at MIT's Martin Trust Center.
Mihir Shah
Mihir ShahPartnerHe is now a Venture Partner at F-Prime and serves on advisory boards.
Muzammil Mansuri
Muzammil MansuriPartnerHe has over 35 years of experience in senior R&D roles in the biopharmaceutical industry.
Sam Bisbee
Sam BisbeePartnerHe joined Threat Stack in 2014 and previously worked at Cloudant.
Sandor Palfy
Sandor PalfyPartnerHe previously served as CTO of LogMeIn and holds a master's degree in Computer Science.
Sanjay Aggarwal
Sanjay AggarwalPartnerFocus: physical and enterprise AI.
Ben Gorman
Ben GormanPrincipalHe previously worked as a managing consultant at IBM and studied Statistics and Economics at Carnegie Mellon University.
Mona VernonInvesting team
Steve SchultzInvesting team
Tristan ZajoncInvesting team

Work here and something is wrong? Ask for a correction.

Writes $1M to $30M+ checks. Its smallest check is larger than 83% of firms in the atlas.

Bars: how many firms in the atlas report each band. Highlighted: this firm.

No recent activity since September 2026. Quiet does not mean closed.

Weekly count of activity updates. Activity is not a confirmed deal.

Before you pitch

Ownership target7-10%
How to reach them[email protected]

Notable investments

AlibabaToastBeam TherapeuticsFlywireDenali TherapeuticsPony.aiNuance CommunicationsSana Biotechnology

In their words

Home - F-Prime CapitalF-Prime Capital is a global venture capital firm investing in life sciences, technology healthtech + services, and crypto, with a heritage that spans four decades.www.fprimecapital.com
Founders and investors at a Mode VC gathering

Send Mode VC your deck

Raising a pre-seed or seed round? We write $1M to $5M first checks and help founders with distribution. A partner reads every deck.

Send your deck

Alert me when F-Prime Capital is active

One email when this firm shows new activity. Nothing else.

Firms like F-Prime Capital

On these lists

Questions

What stage does F-Prime Capital invest in?

F-Prime Capital reports entry at pre-seed, seed, series a, series b.

How much does F-Prime Capital invest?

F-Prime Capital reports checks of $1M to $30M+.

Does F-Prime Capital lead rounds?

Yes. F-Prime Capital says it can lead.

Who are the partners at F-Prime Capital?

Stephen Knight (Senior Managing Partner), Amber Cai (Partner), Carlos Bustamante (Partner), Eric Blatte (Partner), Hannah Arnold (Partner), Harlan Krumholz (Partner).

Is F-Prime Capital active right now?

No recent activity since September 2026.

Work at F-Prime Capital? Claim or correct this profile.