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Pre-seed life sciences investors in Massachusetts

11 of 13 pre-seed life sciences firms that report a preference say they can lead. 1 active since September.

Can leadMostly followsNot reportedRecently active

The EngineActive Sep 22

Massachusetts · Fund $398M (Fund III) (2024)

Ann DeWitt, Israel Ruiz+9 on the team

Pre-seedSeedSeries ALeadsDeep tech +4

$250K to $10MCan lead

Massachusetts · Fund $350M

David Fallace, J.D. / M.B.A., Lou Tartaglia, Ph.D.+13 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +1

Check size not reportedCan lead

Double Point Ventures

Massachusetts

Campbell Murray, Daniel Yadegar

Pre-seedSeedSeries ALeadsLife sciences +1

Check size not reportedCan lead

F-Prime Capital

Massachusetts

Stephen Knight, Amber Cai+17 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +4

$1M to $30M+Can lead

Flagship Pioneering

Massachusetts · Fund $2.6B

Paul Biondi, Doug Cole, M.D.+1 on the team

Pre-seedSeedLeadsLife sciences +2

Check size not reportedCan lead

Massachusetts · Fund $250 million (2025)

Alexander Harstrick, Jonathan Bronson+3 on the team

Pre-seedSeedSeries ALeadsDeep tech +4

$1M to $10MCan lead

Massachusetts

Christoph Westphal, Rich Aldrich+4 on the team

Pre-seedSeedSeries ALeadsLife sciences

Check size not reportedCan lead

Mission BioCapital

Massachusetts · Fund $143.75M

Douglas Crawford, Johannes Fruehauf+10 on the team

Pre-seedSeedSeries ALeadsLife sciences

$25K to $10MCan lead

Qiming Venture Partners USA

Massachusetts · Fund $260 (2022)

Anna French, Mark McDade+4 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +1

$1M to $10MCan lead

RA Capital Management

Massachusetts · Fund $10B+ (2025)

Adam Kaye, Emily Minkow+35 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +4

$3M to $30M+Can lead

SV Health Investors

Massachusetts · Fund $269M (2025)

Greg Madden, Kate Bingham+19 on the team

Pre-seedSeedSeries ASeries BLeadsLife sciences +1

Check size not reportedCan lead

Fast Track Initiative, Inc.

Massachusetts

Hiromichi Kimura, Tomohiro Anzai+1 on the team

Pre-seedSeedSeries ALife sciences +1

Check size not reportedLead not reported

First Star Ventures

Massachusetts

Drew Volpe, Millie Liu+1 on the team

Pre-seedDeep tech +2

Check size not reportedMostly follows

Four Cities Capital

Massachusetts

Ben Hutchinson, George Davies+1 on the team

Pre-seedSeedDev tools and infra +5

Check size not reportedMostly follows

LiquidMetal Ventures

Massachusetts · Fund $10 million (2022)

Ji Zhao, Qiong Ye+2 on the team

Pre-seedSeedSeries ALife sciences +2

Check size not reportedLead not reported

Massachusetts

Myron Kassaraba, Priya Yadav+2 on the team

Pre-seedSeedDeep tech +2

Check size not reportedLead not reported

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Questions

How many pre-seed life sciences investors in massachusetts are there?

Mode VC tracks 16 firms on this list as of 2026-10-15. 1 have been active since September 2026.

What check size do pre-seed life sciences investors in massachusetts write?

The most reported band is $3M to $10M, reported by 6 firms on this list.

Which pre-seed life sciences investors in massachusetts lead rounds?

11 of 13 firms that report a preference say they can lead. Turn on "Leads rounds" to see only them.